Why the 9-plate Vesta H2 is your absolute first choice for the cleanest, healthiest, best-tasting, hydrogen rich water.
Most alkaline water drinkers naturally gravitate toward drinking water that is somewhere between pH 8 to pH 9 for the simple reason it tastes better than water with pH 10 or higher. It is safer too. This poses a problem. You end up drinking water at a low pH that tastes good but doesn’t have beneficial levels of H2. Or to get good H2, you have to drink water with pH 10 or higher, which isn’t palatable - or recommended by the KFDA or Japanese Ministry of Health. Something has to give; you can’t get both.
That is until now. The Vesta H2 outperforms other ionizers in H2, and does so in the recommended - and great tasting – pH 8 to pH 9 range. That gives you the best of both worlds.
The Vesta H2 offers you an industry-best water filtration system, the latest features and finest on-demand Hydrogen generation technology you can buy. It is the zenith in our new H2 Series. The result is you get the safest, cleanest, healthiest - and very importantly - best tasting water.
The Vesta H2: pure perfection.
The New Vesta H2 Water Ionizer offers you these cutting-edge features:
Industry best 13-stage dual-filtration system and UltraWater. Don’t buy an expensive single filter system or one with cheap Vitamin C or carbon filters. The Vesta H2 offers you our UltraWater Technology plus 13 stages of cutting edge filtration to give you the healthiest water that is pristine and ultra-clean!
Nine advanced SmartDesign Electrodes. We do not believe in over-sized or over-powered electrodes, which are often a sign of inefficient design. They degrade faster and have questionable effect in performance. Other ionizers with nine or more electrodes require A LOT of power to run them. Some even have to slow the flow rate. Our engineers found that you get the best performance when you have a highly engineered electrode design matched with proper power density. Our SmartDesign Electrodes are engineered to deliver maximum efficiency. The Vesta H2 offers you the perfect combination of electrode design and count and the optimal power to run them. The result is a great flow rate, top performance, absolute reliability and lasting durability.
Top H2 performance at lower, drinkable levels of pH that taste great! Most other systems can create at least a low level of H2. However, any system that creates decent H2 has to run at a maximum setting and produce water above 10 pH to achieve that result. Not only is it questionable in health terms, but water that high in pH tastes bad! It also stresses the electrodes. The Vesta H2 is better than other systems at delivering H2 performance, especially at lower more drinkable - and safer - pH levels. We can’t stress this point enough. Cleaner, healthier and better tasting water. Step up!
Fully automatic DARC Cleaning System. Clean with every use. We pioneered DARC cleaning. This is simply the best way to help ensure that the most critical component of the ionizer – the electrodes – stays free of scale buildup. Scale is the enemy of performance. The Vesta H2 continues our tradition of offering the best cleaning system so you get great performance, especially over time. It also gives you the peace of mind of never having to think about cleaning or waiting for a cleaning cycle to complete. The Vesta H2 for the best performance and ultimate convenience!
Real-time Flow Control System. Optimal flow rate is also critical in achieving optimal hydrogen performance. The Vesta H2’s Real-time Flow Control System provides you an LCD display and a selectable valve that allows you to set easy and precise control of your flow rate – each time you use it.
AutoAdjust. With AutoAdjust the power can be adjusted to the optimal level for your water ensuring you get peak H2 performance each time you use your Vesta H2.
Top Certifications. Our 13 years in business means you can trust the Vesta H2, AlkaViva and our manufacturing.
Download Technical Specifications Here
“When I was exploring an ideal anti-oxidant that lacks adverse effects, I came across hydrogen. By the first experiment on January 2005, I was amazed at the great protective effects of hydrogen against oxidative stress and decided to devote my life to hydrogen medicine. In 2007, we succeeded in the publication of the first paper in Nature Medicine. This first paper was accepted with a surprise and some doubts, but we overcame them by continuous publications. My mission is to develop not only hydrogen medical sciences, but also hydrogen industry as the pioneer of hydrogen medicine.”
Dr. Shigeo Ohta, Nippon Medical School, Graduate School of Medicine.
Professor, Department of Biochemistry and Cell, Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School.
Hydrogen medicine, Anti-aging, Mitochondrogy.
1970-1974 Department of Chemistry, Faculty of Science, Tokyo University, Japan
1974-1979 Graduate School of Pharmaceutical Sciences, Tokyo University, Japan.
1979-1981 Research associate in Gunma University Graduate School of Medicine, Japan
1981-1985 Research Associate, Biocenter, University of Basel, Switzerland.
1985-1994 Lecture and Associate Professor of Biochemistry, Jichi Medical School, Japan
1994-present Professor, Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nippon Medical School, Japan.
(1)Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S.
Nat Med. 2007 Jun;13(6):688-94. Epub 2007 May 7.
(2)Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice.
Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S.
Neuropsychopharmacology. 2009 Jan;34(2):501-8. doi: 10.1038/npp.2008.95. Epub 2008 Jun 18.
(3)Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice.
Kamimura N, Nishimaki K, Ohsawa I, Ohta S.
Obesity (Silver Spring). 2011 Jul;19(7):1396-403. doi: 10.1038/oby.2011.6. Epub 2011 Feb 3.
(4)Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.
Pharmacol Ther. 2014 Oct;144(1):1-11. doi: 10.1016/j.pharmthera.2014.04.006. Epub 2014 Apr 24.
(5)Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management.
Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Ohta S, Fukuda K, Hori S.
Circulation. 2014 Dec 9;130(24):2173-80. doi: 10.1161/CIRCULATIONAHA.114.011848. Epub 2014 Nov 3.
Selected Additional Studies
(1) Real-time monitoring of oxidative stress in live mouse skin.
Wolf AM, Nishimaki K, Kamimura N, Ohta S.
J Invest Dermatol. 2014 Jun;134(6):1701-9. doi: 10.1038/jid.2013.428. Epub 2013 Oct 15.
(2) Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS.
Rikimaru M, Ohsawa Y, Wolf AM, Nishimaki K, Ichimiya H, Kamimura N, Nishimatsu S, Ohta S, Sunada Y.
Intern Med. 2012;51(24):3351-7. Epub 2012 Dec 15.
(3)Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis.
Shidara Y, Yamagata K, Kanamori T, Nakano K, Kwong JQ, Manfredi G, Oda H, Ohta S.
Cancer Res. 2005 Mar 1;65(5):1655-63.
(4)Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity.
Ohsawa I, Nishimaki K, Murakami Y, Suzuki Y, Ishikawa M, Ohta S.
J Neurosci. 2008 Jun 11;28(24):6239-49. doi: 10.1523/JNEUROSCI.4956-07.2008.
(5)Protection against ischemic brain injury by protein therapeutics.
Asoh S, Ohsawa I, Mori T, Katsura K, Hiraide T, Katayama Y, Kimura M, Ozaki D, Yamagata K, Ohta S.
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17107-12. Epub 2002 Dec 10.
The brain’s blood vessels are lined with endothelial cells that are wedged tightly together, creating a nearly impermeable boundary between the brain and bloodstream. This image shows a section through a blood vessel (black) in the brain of a mouse as well as endothelial cells (surrounded by glial cells in green) and processed from surrounding brain cells (in red).
"Molecular Hydrogen is one of the very few antioxidants that has the ability to penetrate the Blood-Brain Barrier."
Creation Date: 2 July 2014 | Review Date: 2 July 2014
The Blood-Brain BarrierSource: Society for Neuroscience
Author: Mary Bates
The brain is the only organ known to have its own security system, a network of blood vessels that allows the entry of essential nutrients while blocking other substances. Unfortunately, this barrier is so effective at protecting against the passage of foreign substances that it often prevents life-saving drugs from being able to repair the injured or diseased brain. New studies are guiding researchers toward creative ways to open this barrier and “trick” it into allowing medicines to enter.
From hypothesis to visual proof
Every thought you have and action you take requires precise communication between the nerve cells in your brain. For these messages to be successfully transmitted and received, the surrounding environment needs to be stable. In the late 1800s, the surprising results of a routine test set into motion a series of experiments that revealed how the brain separates itself from the natural chemical fluctuations that occur in the body.
Long before German scientist Paul Ehrlich developed a cure for syphilis that would later earn him a Nobel Prize, he was fascinated by the way various tissue types absorb chemical dyes differently. Ehrlich's ultimate goal was to find new compounds that could attack disease-causing microbes. But in the course of this work, he made a strange discovery.
In 1885, Ehrlich injected blue dye into the bloodstream of mice. The dye stained all of the animals' organs blue — except their brains. In a follow-up experiment in 1913, one of Ehrlich's students injected the same dye directly into the brains of mice. This time, the brains turned blue, whereas the other organs did not.
Although these experiments suggested a physical barrier between the brain and the bloodstream, no such barrier could be detected with the instruments of the time.
An intricate network of blood vessels
It took until the 1960s before scientists were able to catch a glimpse of the actual barrier standing between the rest of the body and the brain. Using a microscope that was roughly 5,000 times more powerful than the one Ehrlich used, scientists could see the detailed anatomy of the network of blood vessels in the brain comprising what is now known as the blood-brain barrier.
Similar to all other blood vessels in the body, scientists learned that the brain’s blood vessels are lined with endothelial cells, which serve as an interface between circulating blood and the vessel wall. However, unlike other blood vessels in the body, the endothelial cells in the brain are tightly wedged together, creating a nearly impermeable boundary between the brain and bloodstream.
Bypassing the brain’s barrier
The blood-brain barrier helps block harmful substances, such as toxins and bacteria from entering the brain. But, scientists knew that the brain also depends upon the delivery of hormones and key nutrients, including glucose and several amino acids, from other organs of the body.
To determine how the brain’s bouncer decides which molecules to welcome in and which to turn away, scientists injected chemicals into the bloodstreams of animals and later measured the amount that arrived in the brain.
Gaining entry into the brain
Through extensive study, scientists have found that compounds that are very small and/or fat-soluble, including antidepressants, anti-anxiety medications, alcohol, cocaine, and many hormones are able to slip through the endothelial cells that make up the blood-brain barrier without much effort. In contrast, larger molecules, such as glucose or insulin, must be ferried across by proteins. These transporter proteins, located in the brain's blood vessel walls, selectively snag and pull the desired molecules from the blood into the brain.
Cells within and on either side of the blood-brain barrier are in constant communication about which molecules to let through and when. For instance, if the nerve cells in a region of the brain are working particularly hard, they will signal to the blood vessels to dilate, allowing cell-powering nutrients to quickly travel from the blood to the nerve cells in need.
When the blood-brain barrier breaks down, as is the case in some brain cancers and brain infections or when tiny ruptures to blood vessels occur, some substances that are normally kept out of the brain gain entry and cause problems for the brain.
Some evidence suggests the weakening of the blood-brain barrier may even precede, accelerate, or contribute to a number of neurodegenerative disorders. For instance, studies suggest a leaky blood-brain barrier allows too many white blood cells into the brains of people with multiple sclerosis (MS). With access to the brain, these cells attack myelin, the insulating coating between nerve cells, leading to the disease’s devastating symptoms.
Developing drugs that can penetrate blood-brain barrier
Repairing leaks in the blood-brain barrier is one hurdle for scientists. Another is determining new ways to create openings in the barrier so that life-saving drugs can access the brain.
An estimated 98 percent of potential drug treatments for brain disorders are unable to penetrate the blood-brain barrier. As a result, there are limited options for patients with brain tumors and other neurological diseases.
Barrier crossingsIn light of these challenges, researchers are now developing creative strategies to temporarily open the barrier to allow drugs to reach their targets in the brain.
One way scientists are trying to make the blood-brain barrier more permeable is by administering a solution that sucks water out of the surrounding tissues of an artery leading to the brain. This solution draws water out of the brain's endothelial cells, causing them to shrivel up, which creates gaps through which medications can temporarily pass. Within a couple hours, the cells return to normal size, closing the floodgate again.
This experimental method has been used to successfully deliver chemotherapy drugs to some patients with brain tumors. Researchers also have used this technique to temporarily create gaps in the barrier through which they can thread a microcatheter to deliver anticlotting drugs following a stroke.
Scientists are also developing new strategies for attaching drugs to molecules naturally transported across the barrier. This so-called “Trojan horse” method has shown success in several animal models by enabling drugs otherwise shut out of the brain to get in without adverse effects. However, experts caution such a technique has yet to be tested in clinical trials.
Through the development of new brain technologies, scientists are creating new ways to free up the blood-brain barrier so that life-saving drugs can reach specific targets in the brain without interfering with ongoing activity. Although numerous challenges likely lie ahead, many scientists are hopeful that new knowledge of blood-brain barrier function under normal and diseased conditions will one day lead to better treatments for some of the most challenging and intractable brain diseases.
Boado RJ, Hui EK, Lu JZ, Pardridge WM. Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse. Journal of Pharmacology and Experimental Therapeutics. 333(3): 961-969 (2010).Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease. Pharmacological Reviews. 57:173-185 (2005).
Marquet F, Tung Y, Teichert T, Ferrera VP, Konofagou EE. Noninvasive, transient and selective blood-brain barrier opening in non-human primates in vivo. PLoS One. 6(7): e22598 (2011).
Neuwelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, et al. Engaging neuroscience to advance translational research in brain barrier biology. Nature Reviews Neuroscience. 12(3): 169-182 (2011).
Palmer AM. The blood-brain barrier. Neurobiology of Disease. 37: 1-2. (2010).
Pardridge WM. Drug and gene targeting to the brain with molecular Trojan horses. Nature Reviews Drug Discovery. 1: 131-139 (2002).
Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 57: 178-201 (2008).
Further ReadingKing A. Breaking through the barrier. Chemistry World. June 2011.
Interlandi J. Breaking the brain barrier. Scientific American. May 14, 2011.
Vastag B. Biotechnology: Crossing the barrier. Nature. August 18, 2010.
About the Author
Mary Bates is a freelance science writer interested in the brains and behavior of humans and other animals. For her graduate degree in psychology, she studied the echolocation abilities of big brown bats. She has written for Psychology Today, Scientific American's Mind Matters blog, the Howard Hughes Medical Institute, and other print and online publications.
Download Suisol instructions here:
Downloadable Instructions here:
"Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine"
Published January 2016 in Scientific Research
Following is the Summary of the Article, download the complete report below
"This review and others          have documented that the clinical use of hydrogen is quite promising for the treatment of many acute and chronic illnesses and conditions, as well as its utility in support of the maintenance of good health. What started in Japan and the Far East as preliminary results on the clinical use of hydrogen has now continued there and elsewhere, to the point where there are now a critical number of scientific and clinical studies that support the use of hydrogen as a primary or supportive component of clinical care.
With its potent and unique antioxidant properties, gene regulatory abilities, and rapid rates of diffusion across tissue and cellular barriers, as well as its excellent safety record, hydrogen has many unique characteristics that make it very valuable for utilization in medicine and health. Its systemic properties and excellent penetration ab- ilities allow hydrogen to be effective under conditions of poor blood flow and other situations that limit many other types of systemic treatments.
The clinical justification for hydrogen use is growing because:
1) Redox imbalance and the excess production of ROS and RNS (increasing oxidative stress) have been implicated in many, if not all, pathophysiological mechanisms leading to a wide variety of medical conditions and diseases. Hydrogen is useful because of its potent free-radical scavenging properties that significantly reduce strong cellular oxidants, but it does not affect important signaling pathways that depend on mild cellular oxi- dants.
2) Hydrogen is effective in reducing signs and symptoms and improving quality of life in a wide variety of clinical conditions. Because most of its effects are often indirect, such as reducing excess oxidative stress, hy- drogen is useful for many apparently unrelated clinical conditions that are linked to redox imbalances. Often these conditions do not have definitive treatments that eliminate the illness. In such cases, hydrogen can be used in conjunction with less than effective therapies to improve clinical outcomes.
3) Perhaps its most useful property is that hydrogen does not interfere with the underlying mechanisms of most clinical treatments. Thus, its real value may be in adjuvant therapy, along with standard treatments for many clinical conditions.
4) An important factor is the safety of hydrogen and that no adverse effects of hydrogen have been described. This is also very relevant, since many drugs are limited in their use because of toxicity, adverse reactions, and unfavorable dose-response characteristics. Hydrogen does not have these problems.
5) The ease of hydrogen administration is a useful characteristic. This is where H2-enriched water has an ad- vantage over other methods of hydrogen delivery. Drinking H2-enriched water can be done on a long-term basis without any special requirements for administration.
Basic and clinical research on the use of hydrogen for acute and chronic illnesses will continue to improve our understanding of the mechanism of action of hydrogen therapy.
1) Hydrogen is able to promote changes in the expression and levels of particular proteins by regulating gene expression. Of particular importance is that hydrogen can inhibit or change the expression patterns of pro- inflammatory, pro-allergic, pro-apoptotic and pro-oxidative proteins. Many, if not most, of these proteins are over-expressed in a variety of chronic and acute illnesses. How hydrogen changes the expression of particular proteins remains an important question that is currently a topic of research in several laboratories.
2) The cellular receptors for hydrogen and the mechanisms of hydrogen action at the level of cellular mem- branes, enzymes, protein synthesis, and gene regulation will have to be investigated. Little is actually known about these molecular interactions involving hydrogen inside cells and tissues. This will have to also be investi- gated first in simple in vitro models in order to eventually understand more complex in vivo environments.
3) Hydrogen is able to quickly penetrate into tissues and cells. Further investigation is needed to monitor the actual levels of hydrogen in the microcirculation and target tissues, especially when hydrogen is administered for long periods of time. We do not yet know the levels of hydrogen administration which provide steady state and effective concentrations of hydrogen in various tissues and cells.
4) The clinical uses of hydrogen must be further investigated. Most of the published research on hydrogen has utilized animal models. Although this has been extremely useful, it is now time to shift the focus of research to patients with acute and chronic clinical conditions.
5) There are some advantages and disadvantages in the various ways hydrogen is administered, and this should be further investigated. Although inhalation of H2 gas has an advantage in that it is easy to administer; it also has some disadvantages, such as reproducibility of delivering the same dose of H2 in different patients be- cause of variations in the amounts that effectively reach the microcirculation and tissues. It also requires high- pressure containers and pressure regulators to deliver the required amounts of hydrogen gas, and the patient must use a mask or nasal insert. On the other hand, H2-enriched water can be easily and accurately delivered without any special apparatus. With any delivery method there is the problem of knowing the effective concentrations of hydrogen that reach the target tissues, and this will remain an important research topic.
6) The increased use of controlled, randomized clinical trials will improve our knowledge of the benefits of hydrogen for various acute and chronic conditions. Until recently few clinical trials have used rigorous criteria for evaluation of clinical effects. Many trials have been open label in design, and this is expected for initial clin- ical investigations. In the future it is expected that more carefully designed (and more expensive!) placebo-controlled, blinded, randomized clinical trials will be necessary to confirm the clinical benefits of hydrogen. Finally, the use of hydrogen for acute and chronic medical conditions is rapidly being eclipsed by the use of hydrogen for health maintenance, exercise and physical performance, as well as aging. These areas of hydrogen use will continue to grow and will ultimately dwarf the current clinical uses of hydrogen in our society."
Blog Quick Links